I found this running some ctw tests:

#  Internal Error (/home/roland/jdk-jdk/src/hotspot/share/opto/parse2.cpp:1493), pid=3306856, tid=3306871
#  assert(BoolTest(btest).is_canonical()) failed: sanity

It can be reproduced with the following test case:
public class TestUnsignedCompareIntoEqualityNotCanonical {
    public static void main(String[] args) {
        for (int i = 0; i < 20_000; i++) {
            test(0);
            test(1);
        }
    }

    private static int test(int x) {
        if (Integer.compareUnsigned(0, x) >= 0) {
            return 42;
        }
        return -42;
    }
}